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89 As BH 4 is very susceptible to oxidation, ONOO , resulting from the reaction of NO with superoxide anion, may oxidize BH 4 to the BH 3 radical and, thus, the resulting decrease in endothelial BH 4 can induce eNOS uncoupling

Beside the well-known risk factors such as old age, female gender, and obesity, T2D represents an independent risk factor for cholelithiasis

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